A first-in-human phase 1 trial has reported encouraging safety and antitumor activity with the novel alpha-emitting…
oncology
Combined targeted therapy enhances antitumor immunity in advanced prostate cancer
A previously unidentified immune-suppression pathway has been identified in castration-resistant prostate cancer, revealing how tumors modify…
Bile-based genomic testing of cfDNA may enable earlier detection of biliary tract cancers
Ultra-low-pass whole-genome sequencing (ULP-WGS) of bile cell-free DNA (cfDNA) may improve the early detection of biliary…
Metastatic bladder cancer study reveals how tumors spread and evolve
A study published in Nature has provided new insights into the evolutionary patterns of metastatic bladder…
Coffee consumption and colorectal cancer: Potential mechanisms underlying protective effects
Colorectal cancer (CRC) is one of the most commonly diagnosed malignancies worldwide and remains a major…
Cancer-associated fibroblast–treg cell crosstalk in lung adenocarcinoma: emerging mechanisms and therapeutic implications
Introduction The tumor microenvironment (TME) is a highly complex and dynamic ecosystem comprising malignant cells, stromal cells, extracellular matrix (ECM), and diverse…
New molecular target offers hope for treating aggressive triple-negative breast cancer
Australian researchers have identified a molecular pathway that appears to regulate the spread of triple-negative breast cancer (TNBC), raising the…
Obesity linked to distinct molecular changes that may promote invasive breast cancer
A new study published in The American Journal of Pathology has identified a distinct molecular program linking obesity with the…
ARID1A-mediated chromatin remodeling in gastric epithelial recovery: An emerging barrier against gastric tumorigenesis
The gastric epithelium is continuously exposed to chemical, microbial, and mechanical insults, necessitating highly coordinated processes of tissue…
Chronic stress may help tumors escape immune attack through gut microbes
A new preclinical study has uncovered an unexpected link between chronic psychological stress, gut microbes, and…