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E2F1-mediated cell-cycle re-entry without global chromatin remodelling: Implications for cellular proliferation and cancer
Introduction Cell proliferation is fundamental to embryonic development, tissue maintenance, wound healing and recovery from injury.…
Multi-ancestry genetic study identifies 127 Alzheimer’s disease risk loci and potential therapeutic targets
A large multi-ancestry genetic study published in Nature identified 127 genetic risk loci associated with Alzheimer’s…
Newly identified protein may help protect egg chromosomes from age-related decline
A previously unknown oocyte protein, OMC1, has been identified as a key factor in maintaining chromosome…
Study identifies gene-regulatory pathway that helps prevent gut-driven autoimmunity
Scientists at St. Jude Children’s Research Hospital in the United States have identified a gene-regulatory mechanism…
A novel STAT3 variant reveals a new mechanism of autosomal-dominant immunodeficiency
Signal transducer and activator of transcription 3 (STAT3) is a central transcription factor in cytokine…
Novel alpha-emitting radiopharmaceutical shows promising antitumor activity in advanced prostate cancer
A first-in-human phase 1 trial has reported encouraging safety and antitumor activity with the novel alpha-emitting…
SRSF1 shows promise in reversing cellular aging while preserving cell identity
SRSF1 shows promise in reversing cellular aging while preserving cell identity Aging progressively impairs tissue integrity…
Eating fat before carbohydrates may improve post-meal glucose control through gut–hormone–nerve signaling
The order in which foods are consumed during a meal may influence post-meal blood glucose levels…