Acne vulgaris, characterized by active lesions that can lead to long-term scarring and hyperpigmentation, often has significant psychological effects such as low self-esteem, poor body image, anxiety, depression, and social withdrawal. A recent study published in the International Journal of Dermatology has shown promising results for patients with moderate acne vulgaris and acne-induced hyperpigmentation using a combination of trifarotene and skincare.
The double-blind, parallel-group study, led by Dr. Alexis, included 123 participants aged 13 to 35 with moderate acne vulgaris and acne-induced hyperpigmentation. Participants were treated with either trifarotene or a placebo, along with a prescribed skincare regimen that included moisturizer, cleanser, and sunscreen
Trifarotene 50 µg/g cream was found to be significantly more effective than the vehicle in reducing Off-Face Dermatitis Score (ODS) at week 12, but both groups had comparable scores at week 24. Trifarotene also showed a better reduction in Post-Acne Hyperpigmentation Index (PAHPI) score at Week 24, as well as higher lesion count reductions and Investigator Global Assessment (IGA) success rates at both weeks 12 and 24 compared to the vehicle. During the study, patients reported that the skincare regimen helped reduce irritation, making it easier to comply with treatment. Photographic evidence revealed improvements in pigmentation and erythema across all skin types. Adverse events were less common in the trifarotene group than in the vehicle group (16.7% versus 30.2%, respectively).
The researchers concluded that trifarotene cream is a safe and effective treatment option for moderate acne vulgaris and acne-induced hyperpigmentation on different skin types. The combination of trifarotene with skincare demonstrated high patient satisfaction and adherence to the treatment protocol, underscoring its clinical promise for managing moderate acne and associated hyperpigmentation.
Reference
Alexis A, Del Rosso JQ, Forman S, Martorell A, Browning J, Laquer V, et al. Importance of treating acne sequelae in skin of color: 6-month phase IV study of trifarotene with an appropriate skincare routine including UV protection in acne-induced post-inflammatory hyperpigmentation. International Journal of Dermatology [Internet]. [cited 2024 May 9];n/a(n/a). Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/ijd.17189